V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins.

Zhou, Caihong; Zhou, Yan; Wang, Jia; Feng, Yang; Wang, Haonan; Xue, Jinglun; Chen, Yani; Ye, Richard D; Wang, Ming-Wei

Zhou, Caihong; Zhou, Yan; Wang, Jia; Feng, Yang; Wang, Haonan; Xue, Jinglun; Chen, Yani; Ye, Richard D; Wang, Ming-Wei.

Affiliation

Zhou C; The National Center for Drug Screening, the Chinese Academy of Sciences Key Laboratory of Receptor Research and the State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.

Biochem J ; 451(2): 245-55, 2013 Apr 15.

Article in En | MEDLINE | ID: mdl-23373827

Subject(s)

Cyclosporine/pharmacology; Polymorphism, Single Nucleotide; Receptors, Formyl Peptide/genetics; Receptors, Formyl Peptide/metabolism; Amino Acid Substitution; Animals; Asian People; CHO Cells/drug effects; Calcium/metabolism; Chemotaxis/drug effects; Cricetinae; Cricetulus; Cyclosporins/metabolism; Cyclosporins/pharmacology; Female; Haplotypes; Humans; Male; Mitogen-Activated Protein Kinase 3/metabolism; N-Formylmethionine Leucyl-Phenylalanine/pharmacology; Pharmacogenetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclosporine / Polymorphism, Single Nucleotide / Receptors, Formyl Peptide Limits: Animals / Female / Humans / Male Language: En Journal: Biochem J Year: 2013 Type: Article Affiliation country: China

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