Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b.

Kornfeld, Jan-Wilhelm; Baitzel, Catherina; Könner, A Christine; Nicholls, Hayley T; Vogt, Merly C; Herrmanns, Karolin; Scheja, Ludger; Haumaitre, Cécile; Wolf, Anna M; Knippschild, Uwe; Seibler, Jost; Cereghini, Silvia; Heeren, Joerg; Stoffel, Markus; Brüning, Jens C

Kornfeld, Jan-Wilhelm; Baitzel, Catherina; Könner, A Christine; Nicholls, Hayley T; Vogt, Merly C; Herrmanns, Karolin; Scheja, Ludger; Haumaitre, Cécile; Wolf, Anna M; Knippschild, Uwe; Seibler, Jost; Cereghini, Silvia; Heeren, Joerg; Stoffel, Markus; Brüning, Jens C.

Affiliation

Kornfeld JW; Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Cologne, Germany.

Nature ; 494(7435): 111-5, 2013 Feb 07.

Article in En | MEDLINE | ID: mdl-23389544

Subject(s)

Gene Silencing; Glucose/metabolism; Hepatocyte Nuclear Factor 1-beta/deficiency; MicroRNAs/genetics; Obesity/genetics; Animals; Gene Expression Regulation; Gluconeogenesis; Glucose/biosynthesis; Glucose Intolerance/genetics; Glucose Intolerance/metabolism; Hepatocyte Nuclear Factor 1-beta/genetics; Hepatocyte Nuclear Factor 1-beta/metabolism; Humans; Insulin/metabolism; Insulin Resistance/genetics; Liver/metabolism; Mice; MicroRNAs/biosynthesis; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Silencing / MicroRNAs / Hepatocyte Nuclear Factor 1-beta / Glucose / Obesity Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2013 Type: Article Affiliation country: Germany

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