Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance.

Wang, Wang; Barnabei, Matthew S; Asp, Michelle L; Heinis, Frazer I; Arden, Erik; Davis, Jennifer; Braunlin, Elizabeth; Li, Qi; Davis, Jonathan P; Potter, James D; Metzger, Joseph M

Wang, Wang; Barnabei, Matthew S; Asp, Michelle L; Heinis, Frazer I; Arden, Erik; Davis, Jennifer; Braunlin, Elizabeth; Li, Qi; Davis, Jonathan P; Potter, James D; Metzger, Joseph M.

Affiliation

Wang W; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Nat Med ; 19(3): 305-12, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23396207

Subject(s)

Calcium/metabolism; EF Hand Motifs; Magnesium/metabolism; Myocardial Contraction; Myocytes, Cardiac/physiology; Parvalbumins/chemistry; Parvalbumins/metabolism; Amino Acid Sequence; Amino Acid Substitution; Animals; Calcium-Binding Proteins/chemistry; Calcium-Binding Proteins/metabolism; Calmodulin/chemistry; Calmodulin/metabolism; Female; Heart/physiology; Male; Molecular Sequence Data; Muscle Contraction; Myocardium/metabolism; Protein Structure, Tertiary; Rabbits; Rats; Rats, Sprague-Dawley; Sequence Alignment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parvalbumins / Calcium / EF Hand Motifs / Myocytes, Cardiac / Magnesium / Myocardial Contraction Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2013 Type: Article Affiliation country: United States

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