Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds.

Ngoei, Kevin R W; Ng, Dominic C H; Gooley, Paul R; Fairlie, David P; Stoermer, Martin J; Bogoyevitch, Marie A

Ngoei, Kevin R W; Ng, Dominic C H; Gooley, Paul R; Fairlie, David P; Stoermer, Martin J; Bogoyevitch, Marie A.

Affiliation

Ngoei KR; Department of Biochemistry and Molecular Biology, University of Melbourne, Victoria, Australia.

Biochim Biophys Acta ; 1834(6): 1077-88, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23410953

Subject(s)

Diamines/chemistry; Diamines/pharmacology; Mitogen-Activated Protein Kinase 8/antagonists & inhibitors; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/pharmacology; Thiazoles/chemistry; Thiazoles/pharmacology; Adenosine Triphosphate/metabolism; Animals; Binding Sites; Cell Line; Cells, Cultured; Competitive Bidding; MAP Kinase Signaling System/drug effects; Mice; Mitogen-Activated Protein Kinase 8/chemistry; Mitogen-Activated Protein Kinase 8/metabolism; Models, Molecular; Molecular Docking Simulation/methods; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazoles / Mitogen-Activated Protein Kinase 8 / Protein Kinase Inhibitors / Diamines Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Biochim Biophys Acta Year: 2013 Type: Article Affiliation country: Australia

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