Proximal tubule-dominant transfer of AT(1a) receptors induces blood pressure responses to intracellular angiotensin II in AT(1a) receptor-deficient mice.

Li, Xiao C; Zhuo, Jia L

Li, Xiao C; Zhuo, Jia L.

Affiliation

Li XC; Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Am J Physiol Regul Integr Comp Physiol ; 304(8): R588-98, 2013 Apr 15.

Article in En | MEDLINE | ID: mdl-23427083

Subject(s)

Angiotensin II/pharmacology; Blood Pressure/physiology; Kidney Tubules, Proximal/metabolism; Receptor, Angiotensin, Type 1/genetics; Receptor, Angiotensin, Type 1/metabolism; Vasoconstrictor Agents/pharmacology; Angiotensin II/biosynthesis; Animals; Blood Pressure/drug effects; Blotting, Western; Dependovirus; Drinking/physiology; Electrolytes/urine; Enzyme-Linked Immunosorbent Assay; Genetic Vectors; Green Fluorescent Proteins/genetics; Kidney Tubules, Proximal/drug effects; Low Density Lipoprotein Receptor-Related Protein-2/biosynthesis; Low Density Lipoprotein Receptor-Related Protein-2/genetics; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Angiotensin, Type 1/physiology; Sodium-Glucose Transporter 2/metabolism; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers/biosynthesis; Sodium-Hydrogen Exchangers/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasoconstrictor Agents / Blood Pressure / Angiotensin II / Receptor, Angiotensin, Type 1 / Kidney Tubules, Proximal Limits: Animals Language: En Journal: Am J Physiol Regul Integr Comp Physiol Journal subject: FISIOLOGIA Year: 2013 Type: Article Affiliation country: United States

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