A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Santoro, Fabio; Botrugno, Oronza A; Dal Zuffo, Roberto; Pallavicini, Isabella; Matthews, Geoffrey M; Cluse, Leonie; Barozzi, Iros; Senese, Silvia; Fornasari, Lorenzo; Moretti, Simona; Altucci, Lucia; Pelicci, Pier Giuseppe; Chiocca, Susanna; Johnstone, Ricky W; Minucci, Saverio

Santoro, Fabio; Botrugno, Oronza A; Dal Zuffo, Roberto; Pallavicini, Isabella; Matthews, Geoffrey M; Cluse, Leonie; Barozzi, Iros; Senese, Silvia; Fornasari, Lorenzo; Moretti, Simona; Altucci, Lucia; Pelicci, Pier Giuseppe; Chiocca, Susanna; Johnstone, Ricky W; Minucci, Saverio.

Affiliation

Santoro F; Department of Experimental Oncology at the IFOM-IEO Campus, European Institute of Oncology, via Adamello 16, Milan, Italy.

Blood ; 121(17): 3459-68, 2013 Apr 25.

Article in En | MEDLINE | ID: mdl-23440245

Subject(s)

Cell Transformation, Neoplastic/genetics; Histone Deacetylase 1/genetics; Histone Deacetylase 2/genetics; Leukemia, Promyelocytic, Acute/etiology; Leukemia, Promyelocytic, Acute/prevention & control; Tumor Suppressor Protein p53/physiology; Animals; Blotting, Western; Cell Differentiation/drug effects; Cell Proliferation/drug effects; Cell Transformation, Neoplastic/pathology; Female; Flow Cytometry; Genomic Instability; Histone Deacetylase 1/antagonists & inhibitors; Histone Deacetylase 1/metabolism; Histone Deacetylase 2/antagonists & inhibitors; Histone Deacetylase 2/metabolism; Histone Deacetylase Inhibitors/pharmacology; Leukemia, Promyelocytic, Acute/mortality; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Survival Rate; Tumor Cells, Cultured; Valproic Acid/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Promyelocytic, Acute / Cell Transformation, Neoplastic / Tumor Suppressor Protein p53 / Histone Deacetylase 1 / Histone Deacetylase 2 Limits: Animals Language: En Journal: Blood Year: 2013 Type: Article Affiliation country: Italy

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