The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer.

Thornton, Michael; Aslam, Mohammed A; Tweedle, Elizabeth M; Ang, Chin; Campbell, Fiona; Jackson, Richard; Costello, Eithne; Rooney, Paul S; Vlatkovic, Nikolina; Boyd, Mark T

Thornton, Michael; Aslam, Mohammed A; Tweedle, Elizabeth M; Ang, Chin; Campbell, Fiona; Jackson, Richard; Costello, Eithne; Rooney, Paul S; Vlatkovic, Nikolina; Boyd, Mark T.

Affiliation

Thornton M; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, L3 9TA, United Kingdom.

Int J Cancer ; 133(6): 1408-18, 2013 Sep 15.

Article in En | MEDLINE | ID: mdl-23456958

Subject(s)

Colorectal Neoplasms/drug therapy; Heat-Shock Proteins/physiology; Unfolded Protein Response; Adult; Aged; Apoptosis/drug effects; Biomarkers, Tumor/analysis; Colorectal Neoplasms/chemistry; Colorectal Neoplasms/mortality; Colorectal Neoplasms/pathology; Endoplasmic Reticulum Chaperone BiP; Female; Fluorouracil/pharmacology; Heat-Shock Proteins/analysis; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; Tumor Suppressor Protein p53/analysis

Key words

GRP78; biological markers; colorectal neoplasms; retrospective studies; tumour suppressor protein p53; unfolded protein response

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Unfolded Protein Response / Heat-Shock Proteins Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Int J Cancer Year: 2013 Type: Article Affiliation country: United kingdom

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