Investigation of the phototoxicity and cytotoxicity of naproxen, a non-steroidal anti-inflammatory drug, in human fibroblasts.

Bracchitta, G; Catalfo, A; Martineau, S; Sage, E; De Guidi, G; Girard, P M

Bracchitta, G; Catalfo, A; Martineau, S; Sage, E; De Guidi, G; Girard, P M.

Affiliation

Bracchitta G; Dipartimento di Scienze Chimiche, Università degli Studi di Catania, 95125 Catania, Italy.

Photochem Photobiol Sci ; 12(5): 911-22, 2013 May.

Article in En | MEDLINE | ID: mdl-23478633

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/toxicity; Fibroblasts/drug effects; Naproxen/toxicity; Anti-Inflammatory Agents, Non-Steroidal/chemistry; Cell Line; Cell Survival/drug effects; Checkpoint Kinase 1; DNA Replication/drug effects; DNA Replication/radiation effects; Fibroblasts/metabolism; Fibroblasts/radiation effects; Glutathione/metabolism; Humans; Lipid Peroxidation; Naproxen/chemistry; Oxidation-Reduction; Phosphorylation; Proliferating Cell Nuclear Antigen/chemistry; Proliferating Cell Nuclear Antigen/metabolism; Protein Kinases/chemistry; Protein Kinases/genetics; Protein Kinases/metabolism; RNA Interference; RNA, Small Interfering/metabolism; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Signal Transduction/radiation effects; Tryptophan/chemistry; Tryptophan/metabolism; Ultraviolet Rays; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Naproxen / Fibroblasts Limits: Humans Language: En Journal: Photochem Photobiol Sci Journal subject: BIOLOGIA / QUIMICA Year: 2013 Type: Article Affiliation country: Italy

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