Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA.

Murtaza, Muhammed; Dawson, Sarah-Jane; Tsui, Dana W Y; Gale, Davina; Forshew, Tim; Piskorz, Anna M; Parkinson, Christine; Chin, Suet-Feung; Kingsbury, Zoya; Wong, Alvin S C; Marass, Francesco; Humphray, Sean; Hadfield, James; Bentley, David; Chin, Tan Min; Brenton, James D; Caldas, Carlos; Rosenfeld, Nitzan

Murtaza, Muhammed; Dawson, Sarah-Jane; Tsui, Dana W Y; Gale, Davina; Forshew, Tim; Piskorz, Anna M; Parkinson, Christine; Chin, Suet-Feung; Kingsbury, Zoya; Wong, Alvin S C; Marass, Francesco; Humphray, Sean; Hadfield, James; Bentley, David; Chin, Tan Min; Brenton, James D; Caldas, Carlos; Rosenfeld, Nitzan.

Affiliation

Murtaza M; Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

Nature ; 497(7447): 108-12, 2013 May 02.

Article in En | MEDLINE | ID: mdl-23563269

Subject(s)

Antineoplastic Agents/therapeutic use; DNA, Neoplasm/analysis; DNA, Neoplasm/genetics; Drug Resistance, Neoplasm/genetics; Neoplasms/drug therapy; Neoplasms/genetics; Plasma/chemistry; Alleles; Antineoplastic Agents/pharmacology; Breast Neoplasms/drug therapy; Breast Neoplasms/genetics; Breast Neoplasms/pathology; Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/pathology; Class I Phosphatidylinositol 3-Kinases; DNA Mutational Analysis; Drug Resistance, Neoplasm/drug effects; ErbB Receptors/genetics; Evolution, Molecular; Exome/genetics; Female; Genome, Human/genetics; Genomics; Humans; Intercellular Signaling Peptides and Proteins/genetics; Lung Neoplasms/drug therapy; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Mediator Complex Subunit 1/genetics; Neoplasms/pathology; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/genetics; Ovarian Neoplasms/pathology; Phosphatidylinositol 3-Kinases/genetics; Retinoblastoma Protein/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasma / DNA, Neoplasm / Drug Resistance, Neoplasm / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Nature Year: 2013 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google