Toll-like receptor 9 agonist IMO cooperates with everolimus in renal cell carcinoma by interfering with tumour growth and angiogenesis.

Damiano, V; Rosa, R; Formisano, L; Nappi, L; Gelardi, T; Marciano, R; Cozzolino, I; Troncone, G; Agrawal, S; Veneziani, B M; De Placido, S; Bianco, R; Tortora, G

Damiano, V; Rosa, R; Formisano, L; Nappi, L; Gelardi, T; Marciano, R; Cozzolino, I; Troncone, G; Agrawal, S; Veneziani, B M; De Placido, S; Bianco, R; Tortora, G.

Affiliation

Damiano V; Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università di Napoli Federico II, Naples, Italy.

Br J Cancer ; 108(8): 1616-23, 2013 Apr 30.

Article in En | MEDLINE | ID: mdl-23571736

Subject(s)

Carcinoma, Renal Cell/drug therapy; Kidney Neoplasms/drug therapy; Oligonucleotides/pharmacology; Sirolimus/analogs & derivatives; Toll-Like Receptor 9/agonists; Animals; Carcinoma, Renal Cell/blood supply; Carcinoma, Renal Cell/genetics; Carcinoma, Renal Cell/pathology; Cell Growth Processes/drug effects; Cell Line, Tumor; Drug Synergism; Everolimus; Human Umbilical Vein Endothelial Cells/cytology; Human Umbilical Vein Endothelial Cells/drug effects; Humans; Kidney Neoplasms/blood supply; Kidney Neoplasms/genetics; Kidney Neoplasms/pathology; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic/drug therapy; Neovascularization, Pathologic/pathology; Oligonucleotides/genetics; Oligonucleotides/immunology; Random Allocation; Sirolimus/pharmacology; Toll-Like Receptor 9/genetics; Von Hippel-Lindau Tumor Suppressor Protein/genetics; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Carcinoma, Renal Cell / Sirolimus / Toll-Like Receptor 9 / Kidney Neoplasms Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans Language: En Journal: Br J Cancer Year: 2013 Type: Article Affiliation country: Italy

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