TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.

Su, Liping; Nalle, Sam C; Shen, Le; Turner, Emily S; Singh, Gurminder; Breskin, Lydia A; Khramtsova, Ekaterina A; Khramtsova, Galina; Tsai, Pei-Yun; Fu, Yang-Xin; Abraham, Clara; Turner, Jerrold R

Su, Liping; Nalle, Sam C; Shen, Le; Turner, Emily S; Singh, Gurminder; Breskin, Lydia A; Khramtsova, Ekaterina A; Khramtsova, Galina; Tsai, Pei-Yun; Fu, Yang-Xin; Abraham, Clara; Turner, Jerrold R.

Affiliation

Su L; Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Gastroenterology ; 145(2): 407-15, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23619146

Subject(s)

Colitis/physiopathology; Epithelial Cells/physiology; Intestinal Mucosa/physiopathology; Myosin-Light-Chain Kinase/physiology; Receptors, Tumor Necrosis Factor, Type II/physiology; Receptors, Tumor Necrosis Factor, Type I/physiology; Tight Junctions/physiology; Adoptive Transfer; Animals; Apoptosis/physiology; Claudin-2/metabolism; Colitis/immunology; Colitis/metabolism; Dextran Sulfate; Disease Models, Animal; Epithelial Cells/immunology; Epithelial Cells/metabolism; Inflammatory Bowel Diseases; Intestinal Mucosa/immunology; Intestinal Mucosa/metabolism; Mice; Mice, Inbred C57BL; Myosin Light Chains/metabolism; Myosin Type II/metabolism; Myosin-Light-Chain Kinase/genetics; Permeability; Phosphorylation; Receptors, Tumor Necrosis Factor, Type I/genetics; Receptors, Tumor Necrosis Factor, Type II/genetics; Signal Transduction; Tight Junctions/metabolism; Up-Regulation; Weight Loss

Key words

CA-MLCK; DSS; Disease Progression; Epithelial Barrier; IBD; Inflammatory Bowel Disease; Intestinal Permeability; MLC; MLCK; Rag1; TNF; TNFR; constitutively active myosin light chain kinase; dextran sulfate sodium; inflammatory bowel disease; myosin II regulatory light chain; myosin light chain kinase; recombinase activating gene 1; tumor necrosis factor; tumor necrosis factor receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myosin-Light-Chain Kinase / Colitis / Tight Junctions / Receptors, Tumor Necrosis Factor, Type I / Receptors, Tumor Necrosis Factor, Type II / Epithelial Cells / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals Language: En Journal: Gastroenterology Year: 2013 Type: Article Affiliation country: China

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