Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity.

Makowski, Kamil; Mera, Paula; Paredes, David; Herrero, Laura; Ariza, Xavier; Asins, Guillermina; Hegardt, Fausto G; García, Jordi; Serra, Dolors

Makowski, Kamil; Mera, Paula; Paredes, David; Herrero, Laura; Ariza, Xavier; Asins, Guillermina; Hegardt, Fausto G; García, Jordi; Serra, Dolors.

Affiliation

Makowski K; Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain.

Chirality ; 25(5): 281-7, 2013 May.

Article in En | MEDLINE | ID: mdl-23620264

Subject(s)

4-Butyrolactone/analogs & derivatives; Antineoplastic Agents/pharmacology; Appetite Depressants/pharmacology; 4-Butyrolactone/chemistry; 4-Butyrolactone/pharmacology; Animals; Antineoplastic Agents/chemistry; Appetite Depressants/chemistry; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Appetite Depressants / 4-Butyrolactone / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Chirality Journal subject: BIOLOGIA MOLECULAR / QUIMICA Year: 2013 Type: Article Affiliation country: Spain

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