Evaluation of 2'-&#945;-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase.

Parrish, Jay P; Lee, Sharon K; Boojamra, Constantine G; Hui, Hon; Babusis, Darius; Brown, Brandon; Shih, I-hung; Feng, Joy Y; Ray, Adrian S; Mackman, Richard L

Evaluation of 2'-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase.

Parrish, Jay P; Lee, Sharon K; Boojamra, Constantine G; Hui, Hon; Babusis, Darius; Brown, Brandon; Shih, I-hung; Feng, Joy Y; Ray, Adrian S; Mackman, Richard L.

Affiliation

Parrish JP; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA. Jay.Parrish@gilead.com

Bioorg Med Chem Lett ; 23(11): 3354-7, 2013 Jun 01.

Article in En | MEDLINE | ID: mdl-23639543

Subject(s)

Antiviral Agents/chemistry; DNA-Directed RNA Polymerases/antagonists & inhibitors; Fluorine/chemistry; Hepacivirus/enzymology; Organophosphonates/chemistry; Ribonucleosides/chemistry; Antiviral Agents/chemical synthesis; Antiviral Agents/pharmacology; Cell Line; DNA-Directed RNA Polymerases/metabolism; Drug Evaluation, Preclinical; Humans; Organophosphonates/chemical synthesis; Organophosphonates/pharmacology; Virus Replication/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Ribonucleosides / DNA-Directed RNA Polymerases / Hepacivirus / Organophosphonates / Fluorine Type of study: Evaluation_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States

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