Effect of temozolomide on male gametes: an epigenetic risk to the offspring?

Berthaut, I; Montjean, D; Dessolle, L; Morcel, K; Deluen, F; Poirot, C; Bashamboo, A; McElreavey, K; Ravel, C

Berthaut, I; Montjean, D; Dessolle, L; Morcel, K; Deluen, F; Poirot, C; Bashamboo, A; McElreavey, K; Ravel, C.

Affiliation

Berthaut I; AP-HP; Hopital Tenon, CECOS, 4 rue de la Chine, 75020, Paris, France.

J Assist Reprod Genet ; 30(6): 827-33, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23652788

Subject(s)

Dacarbazine/analogs & derivatives; Germ Cells/drug effects; Glioma/drug therapy; Spermatozoa/drug effects; Adult; DNA Methylation/drug effects; DNA Modification Methylases/metabolism; DNA Repair Enzymes/metabolism; Dacarbazine/administration & dosage; Dacarbazine/adverse effects; Epigenesis, Genetic/genetics; Female; Glioma/complications; Humans; Male; Pregnancy; Proteins/metabolism; RNA, Long Noncoding/metabolism; Spermatogenesis/drug effects; Spermatozoa/cytology; Temozolomide; Tumor Suppressor Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermatozoa / Dacarbazine / Germ Cells / Glioma Type of study: Etiology_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Pregnancy Language: En Journal: J Assist Reprod Genet Journal subject: GENETICA / MEDICINA REPRODUTIVA Year: 2013 Type: Article Affiliation country: France

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