Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli.

Sherman, David J; Okuda, Suguru; Denny, William A; Kahne, Daniel

Sherman, David J; Okuda, Suguru; Denny, William A; Kahne, Daniel.

Affiliation

Sherman DJ; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Str., Cambridge, MA 02138, United States. dsherman@fas.harvard.edu

Bioorg Med Chem ; 21(16): 4846-51, 2013 Aug 15.

Article in En | MEDLINE | ID: mdl-23665139

Subject(s)

ATP-Binding Cassette Transporters/antagonists & inhibitors; Escherichia coli Proteins/antagonists & inhibitors; Escherichia coli/metabolism; Lipopolysaccharides/metabolism; ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Biological Transport; Cell Wall/metabolism; Escherichia coli/drug effects; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Microbial Sensitivity Tests; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/genetics; Small Molecule Libraries/chemistry; Small Molecule Libraries/pharmacology

Key words

ABC transporter; Antibiotics; Gram-negative; Lipopolysaccharide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipopolysaccharides / ATP-Binding Cassette Transporters / Escherichia coli Proteins / Escherichia coli Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States

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