SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activities.

Hong, Sang-Won; Jung, Kyung Hee; Lee, Hee-Seung; Son, Mi Kwon; Yan, Hong Hua; Kang, Nam Sook; Lee, Jongkook; Hong, Soon-Sun

Hong, Sang-Won; Jung, Kyung Hee; Lee, Hee-Seung; Son, Mi Kwon; Yan, Hong Hua; Kang, Nam Sook; Lee, Jongkook; Hong, Soon-Sun.

Affiliation

Hong SW; Department of Biomedical Sciences, College of Medicine, Inha University, 3-ga, Sinheung-dong, Jung-gu, Incheon 400-712, Republic of Korea.

Carcinogenesis ; 34(9): 2156-69, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23671132

Subject(s)

Proto-Oncogene Proteins c-met/metabolism; Saponins/administration & dosage; Stomach Neoplasms/drug therapy; Angiogenesis Inhibitors/administration & dosage; Animals; Antineoplastic Agents/administration & dosage; Apoptosis/drug effects; Cell Proliferation/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Hepatocyte Growth Factor/metabolism; Human Umbilical Vein Endothelial Cells; Humans; Mice; Neovascularization, Pathologic/drug therapy; Neovascularization, Pathologic/genetics; Neovascularization, Pathologic/metabolism; Oncogene Protein v-akt/metabolism; Pulsatilla/chemistry; Rats; Saponins/chemistry; Signal Transduction/drug effects; Stomach Neoplasms/genetics; Stomach Neoplasms/pathology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saponins / Stomach Neoplasms / Proto-Oncogene Proteins c-met Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Carcinogenesis Year: 2013 Type: Article

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