The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.

Ahn, Ryuhjin; Sabourin, Valerie; Ha, Jacqueline R; Cory, Sean; Maric, Gordana; Im, Young Kyuen; Hardy, W Rod; Zhao, Hong; Park, Morag; Hallett, Michael; Siegel, Peter M; Pawson, Tony; Ursini-Siegel, Josie

Ahn, Ryuhjin; Sabourin, Valerie; Ha, Jacqueline R; Cory, Sean; Maric, Gordana; Im, Young Kyuen; Hardy, W Rod; Zhao, Hong; Park, Morag; Hallett, Michael; Siegel, Peter M; Pawson, Tony; Ursini-Siegel, Josie.

Affiliation

Ahn R; Lady Davis Institute for Medical Research, McGill Centre for Bioinformatics, McGill University, Goodman Cancer Research Centre, Montreal, Quebec, Canada.

Cancer Res ; 73(14): 4521-32, 2013 Jul 15.

Article in En | MEDLINE | ID: mdl-23695548

Subject(s)

Breast Neoplasms/metabolism; Phosphotyrosine/metabolism; Shc Signaling Adaptor Proteins/metabolism; Animals; Breast Neoplasms/blood supply; Breast Neoplasms/genetics; Breast Neoplasms/pathology; Cell Line, Tumor; Disease Progression; Female; Fibronectins/metabolism; Humans; Integrin alpha5beta1/metabolism; Mammary Neoplasms, Experimental/blood supply; Mammary Neoplasms, Experimental/genetics; Mammary Neoplasms, Experimental/metabolism; Mammary Neoplasms, Experimental/pathology; Mice; Mice, Transgenic; Mutation; Neovascularization, Pathologic/genetics; Neovascularization, Pathologic/metabolism; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases/metabolism; Shc Signaling Adaptor Proteins/genetics; Signal Transduction; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Phosphotyrosine / Shc Signaling Adaptor Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2013 Type: Article Affiliation country: Canada

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