Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle.

Al-Shboul, Othman; Mahavadi, Sunila; Sriwai, Wimolpak; Grider, John R; Murthy, Karnam S

Al-Shboul, Othman; Mahavadi, Sunila; Sriwai, Wimolpak; Grider, John R; Murthy, Karnam S.

Affiliation

Al-Shboul O; Dept. of Physiology and Biophysics, Virginia Commonwealth Univ., Richmond, VA 23298-0711. skarnam@vcu.edu.

Am J Physiol Gastrointest Liver Physiol ; 305(4): G314-24, 2013 Aug 15.

Article in En | MEDLINE | ID: mdl-23764893

Subject(s)

Cyclic GMP/metabolism; Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism; Gastric Fundus/enzymology; Multidrug Resistance-Associated Proteins/metabolism; Muscle Contraction; Muscle, Smooth/enzymology; Myocytes, Smooth Muscle/enzymology; Pyloric Antrum/enzymology; Adenosine Triphosphate/metabolism; Animals; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases/metabolism; Cyclic Nucleotide Phosphodiesterases, Type 5/genetics; Dose-Response Relationship, Drug; Gastric Fundus/cytology; Gastric Fundus/drug effects; Hydrolysis; Multidrug Resistance-Associated Proteins/genetics; Muscle Contraction/drug effects; Muscle Relaxation; Muscle, Smooth/cytology; Muscle, Smooth/drug effects; Myocytes, Smooth Muscle/drug effects; Nitric Oxide/metabolism; Nitric Oxide Donors/pharmacology; Phenotype; Pyloric Antrum/cytology; Pyloric Antrum/drug effects; RNA Interference; RNA, Messenger/metabolism; Rabbits; Second Messenger Systems; Time Factors; Transfection

Key words

MRP5; cyclic nucleotides; phasic muscle; tonic muscle

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyloric Antrum / Cyclic GMP / Multidrug Resistance-Associated Proteins / Myocytes, Smooth Muscle / Cyclic Nucleotide Phosphodiesterases, Type 5 / Gastric Fundus / Muscle Contraction / Muscle, Smooth Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2013 Type: Article

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