Efficacy and toxicity of intensity-modulated radiation therapy for prostate cancer in Chinese patients.
Hong Kong Med J
; 19(5): 407-15, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23784530
ABSTRACT
OBJECTIVE:
To report the treatment efficacy and toxicity profile of intensitymodulated radiation therapy in Chinese patients with clinically localised prostate cancer.DESIGN:
Historical cohort study.SETTING:
Oncology unit in a university teaching hospital in Hong Kong. PATIENTS Patients with clinically localised prostate cancer undergoing intensity-modulated radiation therapy in our institution between May 2001 and November 2009 were reviewed. MAIN OUTCOMEMEASURES:
The 5-year biochemical failurefree survival, 5-year overall survival, as well as acute/late gastro-intestinal toxicities and genito-urinary toxicities.RESULTS:
A total of 182 patients were treated with prostate intensitymodulated radiation therapy with or without whole-pelvic radiotherapy. The median follow-up was 44 months. The median patient age was 72 years. Overall survival of the cohort was 92% after 5 years. The favourable, intermediate, and unfavourable risk category distributions of the National Comprehensive Cancer Network were 21 (12%), 42 (23%), and 119 (65%), respectively. The 5-year actuarial biochemical failurefree survival rates for patients in these categories were 95%, 82%, and 80%, respectively. Multivariate analysis identified early tumour stage, low pre-treatment prostate-specific antigen levels, and the use of adjuvant androgen deprivation as independent prognostic factors for better biochemical failurefree survival. Grade 2 and 3 late gastro-intestinal/genito-urinary toxicities occurred in 8%/3% and 4%/3% of the patients, respectively.CONCLUSION:
Intensity-modulated radiation therapy for prostate cancer is feasible and safe in the Chinese population. These data are consistent with the results of other series in Caucasian populations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Prostate-Specific Antigen
/
Radiotherapy, Intensity-Modulated
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Hong Kong Med J
Journal subject:
MEDICINA
Year:
2013
Type:
Article