Population pharmacokinetics of tolvaptan in healthy subjects and patients with hyponatremia secondary to congestive heart failure or hepatic cirrhosis.

Van Wart, Scott A; Shoaf, Susan E; Mallikaarjun, Suresh; Mager, Donald E

Van Wart, Scott A; Shoaf, Susan E; Mallikaarjun, Suresh; Mager, Donald E.

Affiliation

Van Wart SA; Institute for Clinical Pharmacodynamics, Latham, NY 12110, USA. svanwart@icpd.com

Biopharm Drug Dispos ; 34(6): 336-47, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23794414

Subject(s)

Benzazepines/pharmacokinetics; Heart Failure/blood; Hyponatremia/blood; Liver Cirrhosis/blood; Models, Biological; Adolescent; Adult; Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Benzazepines/blood; Cross-Over Studies; Double-Blind Method; Female; Heart Failure/complications; Humans; Hyponatremia/etiology; Liver Cirrhosis/complications; Male; Middle Aged; Tolvaptan; Young Adult

Key words

cirrhosis; heart failure; hyponatremia; pharmacokinetics; tolvaptan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzazepines / Heart Failure / Hyponatremia / Liver Cirrhosis / Models, Biological Type of study: Clinical_trials / Etiology_studies / Prognostic_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Biopharm Drug Dispos Year: 2013 Type: Article Affiliation country: United States

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