Chemokine unresponsiveness of chronic lymphocytic leukemia cells results from impaired endosomal recycling of Rap1 and is associated with a distinctive type of immunological anergy.

Pye, Derek S; Rubio, Ignacio; Pusch, Rico; Lin, Ke; Pettitt, Andrew R; Till, Kathleen J

Pye, Derek S; Rubio, Ignacio; Pusch, Rico; Lin, Ke; Pettitt, Andrew R; Till, Kathleen J.

Affiliation

Pye DS; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom.

J Immunol ; 191(3): 1496-504, 2013 Aug 01.

Article in En | MEDLINE | ID: mdl-23804711

Subject(s)

ADP-Ribosylation Factor 1/metabolism; Clonal Anergy/immunology; Leukemia, Lymphocytic, Chronic, B-Cell/immunology; Phospholipase D/metabolism; Telomere-Binding Proteins/metabolism; B-Lymphocytes/immunology; Cell Membrane/metabolism; Chemokine CXCL12/metabolism; Endosomes/metabolism; Enzyme Activation; Humans; Immunoglobulin D/immunology; Immunoglobulin D/metabolism; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism; Lymph Nodes/cytology; Lymph Nodes/immunology; Lymphocyte Function-Associated Antigen-1/metabolism; Lymphocytes/cytology; Lymphocytes/immunology; Lymphocytes/metabolism; Shelterin Complex; Telomere-Binding Proteins/biosynthesis; Transendothelial and Transepithelial Migration/immunology; Tumor Cells, Cultured; rap GTP-Binding Proteins/biosynthesis

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phospholipase D / Leukemia, Lymphocytic, Chronic, B-Cell / Clonal Anergy / ADP-Ribosylation Factor 1 / Telomere-Binding Proteins Type of study: Risk_factors_studies Limits: Humans Language: En Journal: J Immunol Year: 2013 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google