Inhibition of soluble epoxide hydrolase after cardiac arrest/cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival.

Wang, Jianming; Fujiyoshi, Tetsuhiro; Kosaka, Yasuharu; Raybuck, Jonathan D; Lattal, K Matthew; Ikeda, Mizuko; Herson, Paco S; Koerner, Ines P

Wang, Jianming; Fujiyoshi, Tetsuhiro; Kosaka, Yasuharu; Raybuck, Jonathan D; Lattal, K Matthew; Ikeda, Mizuko; Herson, Paco S; Koerner, Ines P.

Affiliation

Wang J; Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA.

J Cereb Blood Flow Metab ; 33(10): 1574-81, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23820647

Subject(s)

Cardiopulmonary Resuscitation; Epoxide Hydrolases/antagonists & inhibitors; Heart Arrest/drug therapy; Heart Arrest/pathology; Microglia/pathology; Neurons/pathology; Animals; Cell Death/drug effects; Cell Survival/drug effects; Chalcones/administration & dosage; Chalcones/therapeutic use; Heart Arrest/enzymology; Heart Arrest/immunology; Interleukin-10/biosynthesis; Interleukin-1beta/biosynthesis; Male; Memory/drug effects; Mice; Mice, Inbred C57BL; Microglia/drug effects; Microglia/immunology; Neurons/drug effects; Neurons/immunology; Tumor Necrosis Factor-alpha/biosynthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiopulmonary Resuscitation / Microglia / Epoxide Hydrolases / Heart Arrest / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Cereb Blood Flow Metab Year: 2013 Type: Article Affiliation country: United States

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