Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex.

Cottrell, Jeffrey R; Levenson, Jonathan M; Kim, Sung Hyun; Gibson, Helen E; Richardson, Kristen A; Sivula, Michael; Li, Bing; Ashford, Crystle J; Heindl, Karen A; Babcock, Ryan J; Rose, David M; Hempel, Chris M; Wiig, Kjesten A; Laeng, Pascal; Levin, Margaret E; Ryan, Timothy A; Gerber, David J

Cottrell, Jeffrey R; Levenson, Jonathan M; Kim, Sung Hyun; Gibson, Helen E; Richardson, Kristen A; Sivula, Michael; Li, Bing; Ashford, Crystle J; Heindl, Karen A; Babcock, Ryan J; Rose, David M; Hempel, Chris M; Wiig, Kjesten A; Laeng, Pascal; Levin, Margaret E; Ryan, Timothy A; Gerber, David J.

Affiliation

Cottrell JR; Galenea Corporation, Wakefield, Massachusetts 01880, USA.

J Neurosci ; 33(27): 10938-49, 2013 Jul 03.

Article in En | MEDLINE | ID: mdl-23825400

Subject(s)

Calcineurin/deficiency; Memory Disorders/metabolism; Memory, Short-Term/physiology; Prefrontal Cortex/metabolism; Synaptic Transmission/physiology; Synaptic Vesicles/metabolism; Adult; Animals; Calcineurin/genetics; Female; Humans; Male; Memory Disorders/genetics; Mice; Mice, Knockout; Middle Aged; Nerve Net/metabolism; Organ Culture Techniques; Synaptic Vesicles/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synaptic Vesicles / Prefrontal Cortex / Synaptic Transmission / Calcineurin / Memory Disorders / Memory, Short-Term Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Neurosci Year: 2013 Type: Article Affiliation country: United States

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