Tetrahedral intermediate in a specific alpha-chymotrypsin inhibitor complex detected by laser Raman spectroscopy.
Science
; 189(4200): 384-6, 1975 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-238285
ABSTRACT
Laser Raman spectroscopy indicates that inhibition of alpha-chymotrypsin by 2-phenylethaneboronic acid occurs in two steps:
(i) the formation of a loosely bound complex, in which the boron remains in a trigonal configuration; and (ii) reaction of the boron with a functional group in the catalytic site of the enzyme, resulting in a reversible, stable tetrahedral adduct.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Boronic Acids
/
Chymotrypsin
Language:
En
Journal:
Science
Year:
1975
Type:
Article