Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma.

Pezuk, J A; Brassesco, M S; Morales, A G; de Oliveira, J C; de Paula Queiroz, R G; Machado, H R; Carlotti, C G; Neder, L; Scrideli, C A; Tone, L G

Pezuk, J A; Brassesco, M S; Morales, A G; de Oliveira, J C; de Paula Queiroz, R G; Machado, H R; Carlotti, C G; Neder, L; Scrideli, C A; Tone, L G.

Affiliation

Pezuk JA; Department of Genetics, Faculty of Medicine of Ribeirão Preto, University of São Paulo.

Cancer Gene Ther ; 20(9): 499-506, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23887645

Subject(s)

Brain Neoplasms/metabolism; Cell Cycle Checkpoints; Cell Cycle Proteins/antagonists & inhibitors; Glioblastoma/metabolism; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Proto-Oncogene Proteins/antagonists & inhibitors; Antineoplastic Agents, Alkylating/administration & dosage; Antineoplastic Agents, Alkylating/pharmacology; Brain Neoplasms/drug therapy; Brain Neoplasms/genetics; Cell Cycle Checkpoints/drug effects; Cell Cycle Checkpoints/genetics; Cell Cycle Proteins/genetics; Cell Death/drug effects; Cell Death/genetics; Cell Line, Tumor; Cell Proliferation/drug effects; Dacarbazine/administration & dosage; Dacarbazine/analogs & derivatives; Dacarbazine/pharmacology; Drug Synergism; Glioblastoma/drug therapy; Glioblastoma/genetics; Humans; Protein Kinase Inhibitors/administration & dosage; Protein Serine-Threonine Kinases/genetics; Proto-Oncogene Proteins/genetics; Temozolomide; Tumor Stem Cell Assay; Polo-Like Kinase 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Glioblastoma / Cell Cycle Proteins / Protein Kinase Inhibitors / Cell Cycle Checkpoints Type of study: Etiology_studies Limits: Humans Language: En Journal: Cancer Gene Ther Journal subject: GENETICA MEDICA / NEOPLASIAS / TERAPEUTICA Year: 2013 Type: Article

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