Transport into brain of buthionine sulfoximine, an inhibitor of glutathione synthesis, is facilitated by esterification and administration of dimethylsulfoxide.

Steinherz, R; Mårtensson, J; Wellner, D; Meister, A

Steinherz, R; Mårtensson, J; Wellner, D; Meister, A.

Affiliation

Steinherz R; Department of Biochemistry, Cornell University Medical College, New York, NY 10021.

Brain Res ; 518(1-2): 115-9, 1990 Jun 04.

Article in En | MEDLINE | ID: mdl-2390716

Subject(s)

Dimethyl Sulfoxide/pharmacology; Methionine Sulfoximine/analogs & derivatives; Animals; Antimetabolites/metabolism; Buthionine Sulfoximine; Glutathione/antagonists & inhibitors; Glutathione/biosynthesis; Kinetics; Methionine Sulfoximine/metabolism; Methionine Sulfoximine/pharmacokinetics; Mice

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Collection: 01-internacional Database: MEDLINE Main subject: Dimethyl Sulfoxide / Methionine Sulfoximine Limits: Animals Language: En Journal: Brain Res Year: 1990 Type: Article

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