Pharmacologic inhibition of PKC&#945; and PKCÎ¸ prevents GVHD while preserving GVL activity in mice.

Haarberg, Kelley M K; Li, Jun; Heinrichs, Jessica; Wang, Dapeng; Liu, Chen; Bronk, Crystina C; Kaosaard, Kane; Owyang, Alexander M; Holland, Sacha; Masuda, Esteban; Tso, Kin; Blazar, Bruce R; Anasetti, Claudio; Beg, Amer A; Yu, Xue-Zhong

Pharmacologic inhibition of PKCα and PKCÎ¸ prevents GVHD while preserving GVL activity in mice.

Haarberg, Kelley M K; Li, Jun; Heinrichs, Jessica; Wang, Dapeng; Liu, Chen; Bronk, Crystina C; Kaosaard, Kane; Owyang, Alexander M; Holland, Sacha; Masuda, Esteban; Tso, Kin; Blazar, Bruce R; Anasetti, Claudio; Beg, Amer A; Yu, Xue-Zhong.

Affiliation

Haarberg KM; Department of Immunology and.

Blood ; 122(14): 2500-11, 2013 Oct 03.

Article in En | MEDLINE | ID: mdl-23908466

Subject(s)

Graft vs Host Disease/prevention & control; Graft vs Leukemia Effect/drug effects; Isoenzymes/antagonists & inhibitors; Protein Kinase C-alpha/antagonists & inhibitors; Protein Kinase C/antagonists & inhibitors; Animals; Cell Separation; Disease Models, Animal; Enzyme Inhibitors/pharmacology; Flow Cytometry; Graft vs Host Disease/enzymology; Hematopoietic Stem Cell Transplantation/adverse effects; Leukemia/therapy; Lymphocyte Activation/drug effects; Lymphoma/therapy; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Protein Kinase C-theta; T-Lymphocytes/drug effects; T-Lymphocytes/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Graft vs Leukemia Effect / Protein Kinase C-alpha / Graft vs Host Disease / Isoenzymes Type of study: Prognostic_studies Limits: Animals Language: En Journal: Blood Year: 2013 Type: Article

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