Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models.

Tai, Wenjiao; Ye, Xuan; Bao, Xiuqi; Zhao, Baozhong; Wang, Xiaoliang; Zhang, Dan

Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models.

Tai, Wenjiao; Ye, Xuan; Bao, Xiuqi; Zhao, Baozhong; Wang, Xiaoliang; Zhang, Dan.

Affiliation

Tai W; State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.
Ye X; State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.
Bao X; State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.
Zhao B; Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Wang X; State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.
Zhang D; State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China. Electronic address: danzhang@imm.ac.cn.

Neuropharmacology ; 75: 201-12, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23916477

Subject(s)

Benzeneacetamides/pharmacology; Encephalitis/drug therapy; Enzyme Activators/pharmacology; Parkinson Disease/complications; Phenols/pharmacology; src-Family Kinases/metabolism; Animals; Apomorphine/pharmacology; Benzeneacetamides/chemistry; Cell Line; Disease Models, Animal; Dopamine Agonists/pharmacology; Dose-Response Relationship, Drug; Encephalitis/etiology; Enzyme Activation/drug effects; Enzyme Activators/chemistry; Exploratory Behavior/drug effects; Lipopolysaccharides/pharmacology; Male; Mice; Motor Activity/drug effects; Parkinson Disease/etiology; Phenols/chemistry; Rats; Rats, Wistar

Key words

DA; DOPAC; HVA; Iba-1; LPS; NADPH; NADPH oxidase; NF-κB; NO; Neuroinflammation; ORP; PD; PI3K; Parkinson's disease; ROS; SN; Src tyrosine kinase; TH; TLRs; dihydroxyphenylacetic acid; dopamine; homovanillic acid; ionized calcium binding adaptor molecule-1; lipopolysaccharide; nicotinamide adenine dinucleotide phosphate; nitric oxide; nuclear factor κB; overall rod performance; phosphorylated phosphoinositide 3-kinase; reactive oxygen species; substantia nigra; toll-like receptors; tyrosine hydroxylase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Phenols / Src-Family Kinases / Enzyme Activators / Benzeneacetamides / Encephalitis Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Neuropharmacology Year: 2013 Type: Article Affiliation country: China

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