Synthesis and biological evaluation of flexible and conformationally constrained LpxC inhibitors.

Löppenberg, Marius; Müller, Hannes; Pulina, Carla; Oddo, Alberto; Teese, Mark; Jose, Joachim; Holl, Ralph

Löppenberg, Marius; Müller, Hannes; Pulina, Carla; Oddo, Alberto; Teese, Mark; Jose, Joachim; Holl, Ralph.

Affiliation

Löppenberg M; Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.

Org Biomol Chem ; 11(36): 6056-70, 2013 Sep 28.

Article in En | MEDLINE | ID: mdl-23917427

Subject(s)

Amidohydrolases/antagonists & inhibitors; Anti-Bacterial Agents/pharmacology; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Escherichia coli/drug effects; Glycosides/pharmacology; Hydroxamic Acids/pharmacology; Amidohydrolases/metabolism; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/chemistry; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemistry; Escherichia coli/enzymology; Glycosides/chemical synthesis; Glycosides/chemistry; Hydroxamic Acids/chemical synthesis; Hydroxamic Acids/chemistry; Microbial Sensitivity Tests; Molecular Conformation; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Escherichia coli / Amidohydrolases / Glycosides / Hydroxamic Acids / Anti-Bacterial Agents Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: Germany

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