Loss of PPARÎ³ expression in mammary secretory epithelial cells creates a pro-breast tumorigenic environment.

Apostoli, Anthony J; Skelhorne-Gross, Graham E A; Rubino, Rachel E; Peterson, Nichole T; Di Lena, Michael A; Schneider, Mark M; SenGupta, Sandip K; Nicol, Christopher J B

Apostoli, Anthony J; Skelhorne-Gross, Graham E A; Rubino, Rachel E; Peterson, Nichole T; Di Lena, Michael A; Schneider, Mark M; SenGupta, Sandip K; Nicol, Christopher J B.

Affiliation

Apostoli AJ; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.

Int J Cancer ; 134(5): 1055-66, 2014 Mar 01.

Article in En | MEDLINE | ID: mdl-23934545

Subject(s)

Mammary Glands, Animal/metabolism; Mammary Neoplasms, Experimental/etiology; PPAR gamma/physiology; 9,10-Dimethyl-1,2-benzanthracene; Animals; Epithelial Cells/metabolism; Female; Mammary Neoplasms, Experimental/metabolism; Mice; Mice, Knockout; PTEN Phosphohydrolase/analysis; bcl-2-Associated X Protein/analysis

Key words

PPARÎ³; breast cancer; chemical carcinogenesis; chemotherapy; knockout mouse model; mammary secretory epithelial cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: PPAR gamma / Mammary Glands, Animal / Mammary Neoplasms, Experimental Limits: Animals Language: En Journal: Int J Cancer Year: 2014 Type: Article Affiliation country: Canada

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