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Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin.
Du, Wa; Gerald, Damien; Perruzzi, Carole A; Rodriguez-Waitkus, Paul; Enayati, Ladan; Krishnan, Bhuvaneswari; Edmonds, Joseph; Hochman, Marcelo L; Lev, Dina C; Phung, Thuy L.
Affiliation
  • Du W; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Lab Invest ; 93(10): 1115-27, 2013 Oct.
Article in En | MEDLINE | ID: mdl-23938603
Subject(s)
Antibiotics, Antineoplastic/therapeutic use; Hemangioma, Capillary/drug therapy; Hemangiosarcoma/drug therapy; Neoplastic Syndromes, Hereditary/drug therapy; Protein Kinase Inhibitors/therapeutic use; Ribosomal Protein S6 Kinases, 70-kDa/antagonists & inhibitors; Signal Transduction/drug effects; Sirolimus/therapeutic use; Administration, Topical; Adolescent; Adult; Aged; Animals; Antibiotics, Antineoplastic/administration & dosage; Antibiotics, Antineoplastic/pharmacology; Cell Line, Tumor; Child; Female; Hemangioma, Capillary/epidemiology; Hemangioma, Capillary/metabolism; Hemangioma, Capillary/pathology; Hemangiosarcoma/epidemiology; Hemangiosarcoma/metabolism; Hemangiosarcoma/pathology; Humans; Infant; Male; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Nude; Multiprotein Complexes/antagonists & inhibitors; Multiprotein Complexes/metabolism; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Neoplastic Syndromes, Hereditary/epidemiology; Neoplastic Syndromes, Hereditary/metabolism; Neoplastic Syndromes, Hereditary/pathology; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/pharmacology; Ribosomal Protein S6 Kinases, 70-kDa/genetics; Ribosomal Protein S6 Kinases, 70-kDa/metabolism; Sirolimus/administration & dosage; Sirolimus/pharmacology; TOR Serine-Threonine Kinases/antagonists & inhibitors; TOR Serine-Threonine Kinases/metabolism; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Syndromes, Hereditary / Signal Transduction / Hemangioma, Capillary / Sirolimus / Ribosomal Protein S6 Kinases, 70-kDa / Protein Kinase Inhibitors / Hemangiosarcoma / Antibiotics, Antineoplastic Type of study: Prognostic_studies Language: En Journal: Lab Invest Year: 2013 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Syndromes, Hereditary / Signal Transduction / Hemangioma, Capillary / Sirolimus / Ribosomal Protein S6 Kinases, 70-kDa / Protein Kinase Inhibitors / Hemangiosarcoma / Antibiotics, Antineoplastic Type of study: Prognostic_studies Language: En Journal: Lab Invest Year: 2013 Type: Article Affiliation country: United States