PARP-1 regulates expression of TGF-ß receptors in T cells.
Blood
; 122(13): 2224-32, 2013 Sep 26.
Article
in En
| MEDLINE
| ID: mdl-23940283
ABSTRACT
Transforming growth factor-ß (TGF-ß) receptors (TßRs) are essential components for TGF-ß signal transduction in T cells, yet the mechanisms by which the receptors are regulated remain poorly understood. We show here that Poly(ADP-ribose) polymerase-1 (PARP-1) regulates TGF-ß receptor I (TßRI) and II (TßRII) expression in CD4(+) T cells and subsequently affects Smad2/3-mediated TGF-ß signal transduction. Inhibition of PARP-1 led to the upregulation of both TßRI and TßRII, yet the underlying molecular mechanisms were distinct. PARP-1 selectively bound to the promoter of TßRII, whereas the enzymatic activity of PARP-1 was responsible for the inhibition of TßRI expression. Importantly, inhibition of PARP-1 also enhanced expression of TßRs in human CD4(+) T cells. Thus, PARP-1 regulates TßR expression and TGF-ß signaling in T cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
CD4-Positive T-Lymphocytes
/
Signal Transduction
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Poly(ADP-ribose) Polymerases
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Receptors, Transforming Growth Factor beta
Limits:
Animals
/
Humans
Language:
En
Journal:
Blood
Year:
2013
Type:
Article