Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.

Huang, Zhi-Hong; Zhuo, Shi-Tian; Li, Chun-Yan; Xie, Hua-Ting; Li, Ding; Tan, Jia-Heng; Ou, Tian-Miao; Huang, Zhi-Shu; Gu, Lian-Quan; Huang, Shi-Liang

Huang, Zhi-Hong; Zhuo, Shi-Tian; Li, Chun-Yan; Xie, Hua-Ting; Li, Ding; Tan, Jia-Heng; Ou, Tian-Miao; Huang, Zhi-Shu; Gu, Lian-Quan; Huang, Shi-Liang.

Affiliation

Huang ZH; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.

Eur J Med Chem ; 68: 58-71, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23968711

Subject(s)

Click Chemistry; Naphthoquinones/chemical synthesis; Naphthoquinones/pharmacology; Sesquiterpenes/chemical synthesis; Sesquiterpenes/pharmacology; Topoisomerase II Inhibitors/chemical synthesis; Topoisomerase II Inhibitors/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Binding Sites; Cell Line, Tumor; Enzyme Activation/drug effects; HL-60 Cells; HeLa Cells; Humans; Inhibitory Concentration 50; K562 Cells; Molecular Docking Simulation; Naphthoquinones/chemistry; Protein Binding/drug effects; Sesquiterpenes/chemistry; Topoisomerase II Inhibitors/chemistry

Key words

Antitumour; Click chemistry; Cytotoxic activity; HPLC; HRMS; High Performance Liquid Chromatography; High Resolution Mass Spectrometer; ME; MF; MTT; Mansonone E; NMR; Topo; Topoisomerase; mansonone E; mansonone F; methyl thiazolyl tetrazolium; nuclear magnetic resonance; topoisomerase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Naphthoquinones / Topoisomerase II Inhibitors / Click Chemistry Limits: Humans Language: En Journal: Eur J Med Chem Year: 2013 Type: Article

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