Complete regression of glioblastoma by mesenchymal stem cells mediated prodrug gene therapy simulating clinical therapeutic scenario.

Altaner, Cestmir; Altanerova, Veronika; Cihova, Marina; Ondicova, Katarina; Rychly, Boris; Baciak, Ladislav; Mravec, Boris

Altaner, Cestmir; Altanerova, Veronika; Cihova, Marina; Ondicova, Katarina; Rychly, Boris; Baciak, Ladislav; Mravec, Boris.

Affiliation

Altaner C; Cancer Research Institute, Slovak Academy of Sciences, Laboratory of Molecular Oncology, Bratislava, Slovakia; St. Elisabeth Cancer Institute, Center for Cell Therapy and Regenerative Medicine, Bratislava, Slovakia.

Int J Cancer ; 134(6): 1458-65, 2014 Mar 15.

Article in En | MEDLINE | ID: mdl-24038033

Subject(s)

Brain Neoplasms/prevention & control; Cytosine Deaminase/genetics; Genetic Therapy; Glioblastoma/prevention & control; Mesenchymal Stem Cell Transplantation; Pentosyltransferases/genetics; Prodrugs/therapeutic use; Adipose Tissue/cytology; Adipose Tissue/metabolism; Animals; Antimetabolites/therapeutic use; Bone Marrow/metabolism; Bone Marrow/pathology; Brain Neoplasms/drug therapy; Brain Neoplasms/genetics; Cell Proliferation; Cells, Cultured; Combined Modality Therapy; Flucytosine/therapeutic use; Genetic Vectors; Glioblastoma/drug therapy; Glioblastoma/genetics; Humans; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley

Key words

5-fluorocytosine; CDy::UPRT; glioblastoma; suicide gene therapy; therapeutic stem cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pentosyltransferases / Brain Neoplasms / Prodrugs / Genetic Therapy / Glioblastoma / Cytosine Deaminase / Mesenchymal Stem Cell Transplantation Limits: Animals / Humans / Male Language: En Journal: Int J Cancer Year: 2014 Type: Article Affiliation country: Slovakia

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