cGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury.

Whitaker, Ryan M; Wills, Lauren P; Stallons, L Jay; Schnellmann, Rick G

Whitaker, Ryan M; Wills, Lauren P; Stallons, L Jay; Schnellmann, Rick G.

Affiliation

Whitaker RM; Center for Cell Death, Injury, and Regeneration, Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina; and Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.

J Pharmacol Exp Ther ; 347(3): 626-34, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24042162

Subject(s)

3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors; Acute Kidney Injury/drug therapy; Acute Kidney Injury/metabolism; Mitochondria/drug effects; Phosphodiesterase Inhibitors/pharmacology; Phosphodiesterase Inhibitors/therapeutic use; Acute Kidney Injury/chemically induced; Adenosine Triphosphate/metabolism; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Gene Expression/drug effects; Hematinics; Kidney Cortex/drug effects; Kidney Cortex/metabolism; Male; Mice; Mice, Inbred C57BL; Mitochondria/genetics; Oxygen Consumption/drug effects; Phosphodiesterase 3 Inhibitors/pharmacology; Phosphodiesterase 4 Inhibitors/pharmacology; Phosphodiesterase 5 Inhibitors/pharmacology; Piperazines/pharmacology; Purines/pharmacology; Rabbits; Real-Time Polymerase Chain Reaction; Sildenafil Citrate; Sulfones/pharmacology; Uncoupling Agents/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / 3',5'-Cyclic-AMP Phosphodiesterases / Acute Kidney Injury / Mitochondria Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2013 Type: Article

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