Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists.

Zeng, Qingbei; Rosenblum, Stuart B; Yang, Zhaoxia; Jiang, Yueheng; McCormick, Kevin D; Aslanian, Robert G; Duguma, Luli; Kozlowski, Joseph A; Shih, Neng-Yang; Hey, John A; West, Robert E; Korfmacher, Walter A; Berlin, Michael; Boyce, Christopher W

Zeng, Qingbei; Rosenblum, Stuart B; Yang, Zhaoxia; Jiang, Yueheng; McCormick, Kevin D; Aslanian, Robert G; Duguma, Luli; Kozlowski, Joseph A; Shih, Neng-Yang; Hey, John A; West, Robert E; Korfmacher, Walter A; Berlin, Michael; Boyce, Christopher W.

Affiliation

Zeng Q; Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA.

Bioorg Med Chem Lett ; 23(21): 6001-3, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-24050887

Subject(s)

Benzimidazoles/chemistry; Benzimidazoles/pharmacology; Histamine H3 Antagonists/chemistry; Histamine H3 Antagonists/pharmacology; Animals; Benzimidazoles/chemical synthesis; Benzimidazoles/pharmacokinetics; Cytochrome P-450 Enzyme System/metabolism; Guinea Pigs; Histamine H3 Antagonists/chemical synthesis; Histamine H3 Antagonists/pharmacokinetics; Humans; Rats; Receptors, Histamine H3/metabolism; Structure-Activity Relationship

Key words

Benzimidazolone; H(3)-antagonists; P450 inhibition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Histamine H3 Antagonists Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States

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