Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation.

Erickson, Jeffrey R; Pereira, Laetitia; Wang, Lianguo; Han, Guanghui; Ferguson, Amanda; Dao, Khanha; Copeland, Ronald J; Despa, Florin; Hart, Gerald W; Ripplinger, Crystal M; Bers, Donald M

Erickson, Jeffrey R; Pereira, Laetitia; Wang, Lianguo; Han, Guanghui; Ferguson, Amanda; Dao, Khanha; Copeland, Ronald J; Despa, Florin; Hart, Gerald W; Ripplinger, Crystal M; Bers, Donald M.

Affiliation

Erickson JR; Department of Pharmacology, University of California, Davis, Davis, California 95616, USA.

Nature ; 502(7471): 372-6, 2013 Oct 17.

Article in En | MEDLINE | ID: mdl-24077098

Subject(s)

Arrhythmias, Cardiac/metabolism; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism; Diabetes Complications/metabolism; Hyperglycemia/metabolism; Acetylglucosamine/metabolism; Animals; Arrhythmias, Cardiac/complications; Arrhythmias, Cardiac/enzymology; Benzylamines/pharmacology; Brain/drug effects; Brain/enzymology; Calcium/metabolism; Diabetes Complications/enzymology; Diazooxonorleucine/pharmacology; Enzyme Activation/drug effects; Glucose/metabolism; Glucose/pharmacology; Glycosylation/drug effects; Humans; Hyperglycemia/complications; Hyperglycemia/enzymology; Mice; Myocardium/cytology; Myocardium/enzymology; Myocytes, Cardiac/enzymology; Myocytes, Cardiac/metabolism; Rats; Sarcoplasmic Reticulum/metabolism; Sulfonamides/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arrhythmias, Cardiac / Diabetes Complications / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Hyperglycemia Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2013 Type: Article Affiliation country: United States

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