The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction.

Martelli, A; Testai, L; Anzini, M; Cappelli, A; Di Capua, A; Biava, M; Poce, G; Consalvi, S; Giordani, A; Caselli, G; Rovati, L; Ghelardini, C; Patrignani, P; Sautebin, L; Breschi, M C; Calderone, V

Martelli, A; Testai, L; Anzini, M; Cappelli, A; Di Capua, A; Biava, M; Poce, G; Consalvi, S; Giordani, A; Caselli, G; Rovati, L; Ghelardini, C; Patrignani, P; Sautebin, L; Breschi, M C; Calderone, V.

Affiliation

Martelli A; Dipartimento di Farmacia, Università di Pisa, Via Bonanno, 6, I-56126 Pisa, Italy.

Pharmacol Res ; 78: 1-9, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24083950

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Cyclooxygenase 2 Inhibitors/pharmacology; Endothelium-Dependent Relaxing Factors/administration & dosage; Endothelium/drug effects; Hypertension/drug therapy; Nitrates/pharmacology; Nitric Oxide/administration & dosage; Pyrroles/pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal/chemistry; Blood Pressure/drug effects; Coronary Vessels/drug effects; Cyclooxygenase 2 Inhibitors/chemistry; Endothelium/pathology; Endothelium-Dependent Relaxing Factors/pharmacology; Hypertension/blood; Male; Nitrates/blood; Nitrates/chemistry; Nitric Oxide/pharmacology; Nitrites/blood; Pyrroles/chemistry; Rats; Rats, Inbred SHR; Rats, Wistar; Regional Blood Flow/drug effects

Key words

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one; 2-[2-[1-(4-Fluorophenyl)-2-methyl-5-(4-methylsulfonylphenyl)pyrrol-3-yl]ethoxy]ethanol; 2-[2-[1-(4-Fluorophenyl)-2-methyl-5-(4-methylsulfonylphenyl)pyrrol-3-yl]ethoxy]ethanol (PubChem CID: 56929591); 2-[2-[1-(4-Fluorophenyl)-2-methyl-5-(4-methylsulfonylphenyl)pyrrol-3-yl]ethoxy]ethyl nitrate; 2-[2-[1-(4-Fluorophenyl)-2-methyl-5-(4-methylsulfonylphenyl)pyrrol-3-yl]ethoxy]ethyl nitrate (PubChem CID: 56929588); ACh; ANOVA; APPROVe; Adenomatous Polyp PRevention On Vioxx study; Anti-inflammatory drugs; BP; CINOD; COX(2); COX(2)-inhibitors; COX(2)-selective inhibitors; COX-inhibiting nitric oxide donor; COXIBs; CV; DMSO; Endothelial dysfunction; GC; HR; Hypertension; IL-1ß; LVDP; NA; NO; NO-naproxen (PubChem CID: 9884642); NR; NSAIDs; Nitric oxide-releasing drugs; ODQ; Pharmacodynamic hybrids; RB; SBP; SEM; SHRs; SNP; VA692; VA694; VIGOR; Vioxx Gastrointestinal Outcome studies; acetylcholine; analysis of variance; blood pressure; cardiovascular; cyclooxygenase-2; dimethylsulphoxide; guanylate cyclase; heart rate; interleukine-1ß; left ventricular developed pressure; nitrate reductase bars; nitric oxide; non-steroidal anti-inflammatory drugs; noradrenaline; resuspending buffer; sodium nitroprusside; spontaneously hypertensive rats; standard error of the mean; systolic blood pressure; tNSAIDs; traditional non-steroidal anti-inflammatory drugs

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Anti-Inflammatory Agents, Non-Steroidal / Endothelium-Dependent Relaxing Factors / Endothelium / Cyclooxygenase 2 Inhibitors / Hypertension / Nitrates / Nitric Oxide Type of study: Prognostic_studies Limits: Animals Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2013 Type: Article Affiliation country: Italy

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