Labeling of islet cells with iron oxide nanoparticles through DNA hybridization for highly sensitive detection by MRI.

Kitamura, Narufumi; Nakai, Ryusuke; Kohda, Haruyasu; Furuta-Okamoto, Keiko; Iwata, Hiroo

Kitamura, Narufumi; Nakai, Ryusuke; Kohda, Haruyasu; Furuta-Okamoto, Keiko; Iwata, Hiroo.

Affiliation

Kitamura N; Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

Bioorg Med Chem ; 21(22): 7175-81, 2013 Nov 15.

Article in En | MEDLINE | ID: mdl-24084295

Subject(s)

Contrast Media/chemistry; DNA, Single-Stranded/chemistry; Ferric Compounds/chemistry; Islets of Langerhans/diagnostic imaging; Magnetic Resonance Imaging; Metal Nanoparticles/chemistry; Animals; Cells, Cultured; Contrast Media/metabolism; Islets of Langerhans/chemistry; Islets of Langerhans/metabolism; Islets of Langerhans Transplantation; Male; Maleates/chemistry; Microscopy, Electron, Transmission; Nucleic Acid Hybridization; Phosphatidylethanolamines/chemistry; Polyethylene Glycols/chemistry; Radiography; Rats; Rats, Wistar; Thymidine Monophosphate/chemistry

Key words

Contrast agent; DNA hybridization; Islet; MRI; SPIO; Surface modification; ssDNAPEGphospholipid conjugates

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Single-Stranded / Magnetic Resonance Imaging / Ferric Compounds / Islets of Langerhans / Contrast Media / Metal Nanoparticles Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: Japan

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