GLP-1-derived nonapeptide GLP-1(28-36)amide represses hepatic gluconeogenic gene expression and improves pyruvate tolerance in high-fat diet-fed mice.

Ip, Wilfred; Shao, Weijuan; Chiang, Yu-Ting Alex; Jin, Tianru

Ip, Wilfred; Shao, Weijuan; Chiang, Yu-Ting Alex; Jin, Tianru.

Affiliation

Ip W; Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada;

Am J Physiol Endocrinol Metab ; 305(11): E1348-58, 2013 Dec 01.

Article in En | MEDLINE | ID: mdl-24085036

Subject(s)

Diet, High-Fat; Glucagon-Like Peptide 1/pharmacology; Gluconeogenesis/drug effects; Liver/drug effects; Peptide Fragments/pharmacology; Pyruvic Acid/adverse effects; Animals; Body Weight/drug effects; Cells, Cultured; Diet, High-Fat/adverse effects; Down-Regulation/drug effects; Down-Regulation/genetics; Drug-Related Side Effects and Adverse Reactions/prevention & control; Gene Expression/drug effects; Gluconeogenesis/genetics; Glucose Tolerance Test; Liver/metabolism; Male; Mice; Mice, Inbred C57BL; Pyruvic Acid/metabolism

Key words

adenosine 3',5'-cyclic monophosphate; glucagon-like peptide-1; hepatic glucose production; protein kinase A; type 2 diabetes

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Pyruvic Acid / Glucagon-Like Peptide 1 / Diet, High-Fat / Gluconeogenesis / Liver Limits: Animals Language: En Journal: Am J Physiol Endocrinol Metab Journal subject: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Year: 2013 Type: Article

Fulltext

XML

PubMed Links

Search on Google