Gestational exposure to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induces BRCA-1 promoter hypermethylation and reduces BRCA-1 expression in mammary tissue of rat offspring: preventive effects of resveratrol.

Papoutsis, Andreas J; Selmin, Ornella I; Borg, Jamie L; Romagnolo, Donato F

Papoutsis, Andreas J; Selmin, Ornella I; Borg, Jamie L; Romagnolo, Donato F.

Affiliation

Papoutsis AJ; Department of Nutritional Sciences and Arizona Cancer Center, The University of Arizona, Tucson, Arizona.

Mol Carcinog ; 54(4): 261-9, 2015 Apr.

Article in En | MEDLINE | ID: mdl-24136580

Subject(s)

Breast Neoplasms/chemically induced; Breast Neoplasms/prevention & control; Genes, BRCA1/drug effects; Maternal Exposure/adverse effects; Polychlorinated Dibenzodioxins/toxicity; Receptors, Aryl Hydrocarbon/agonists; Stilbenes/therapeutic use; Teratogens/toxicity; Animals; Anticarcinogenic Agents/therapeutic use; BRCA1 Protein/genetics; Breast/drug effects; Breast/pathology; Breast Neoplasms/pathology; DNA Methylation/drug effects; Epigenesis, Genetic/drug effects; Female; Gene Expression Regulation, Developmental/drug effects; Pregnancy; Promoter Regions, Genetic/drug effects; Rats, Sprague-Dawley; Resveratrol

Key words

BRCA-1; aromatic hydrocarbon receptor; epigenetics; mammary carcinogenesis; resveratrol

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stilbenes / Teratogens / Breast Neoplasms / Receptors, Aryl Hydrocarbon / Maternal Exposure / Genes, BRCA1 / Polychlorinated Dibenzodioxins Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Pregnancy Language: En Journal: Mol Carcinog Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2015 Type: Article

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