Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.

Du, Lai-Ling; Xie, Jia-Zhao; Cheng, Xiang-Shu; Li, Xiao-Hong; Kong, Fan-Li; Jiang, Xia; Ma, Zhi-Wei; Wang, Jian-Zhi; Chen, Chen; Zhou, Xin-Wen

Du, Lai-Ling; Xie, Jia-Zhao; Cheng, Xiang-Shu; Li, Xiao-Hong; Kong, Fan-Li; Jiang, Xia; Ma, Zhi-Wei; Wang, Jian-Zhi; Chen, Chen; Zhou, Xin-Wen.

Affiliation

Du LL; Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Ministry of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Age (Dordr) ; 36(2): 613-23, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24142524

Subject(s)

Cerebral Ventricles/metabolism; Cognition Disorders/drug therapy; Cognition/drug effects; Hippocampus/drug effects; Sirtuin 1/biosynthesis; Stilbenes/administration & dosage; Aging; Animals; Antioxidants/administration & dosage; Blotting, Western; Cerebral Ventricles/drug effects; Cerebral Ventricles/physiopathology; Cognition Disorders/chemically induced; Cognition Disorders/metabolism; Disease Models, Animal; Fluorometry; Hippocampus/metabolism; Hippocampus/physiopathology; Injections, Intraperitoneal; MAP Kinase Signaling System/drug effects; Male; Phosphorylation/drug effects; Rabbits; Rats; Rats, Sprague-Dawley; Resveratrol; Sirtuin 1/drug effects; Streptozocin/toxicity; Vasodilator Agents; tau Proteins/drug effects; tau Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stilbenes / Cerebral Ventricles / Cognition / Cognition Disorders / Sirtuin 1 / Hippocampus Limits: Animals Language: En Journal: Age (Dordr) Year: 2014 Type: Article Affiliation country: China

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