Identification and rescue of &#945;-synuclein toxicity in Parkinson patient-derived neurons.

Chung, Chee Yeun; Khurana, Vikram; Auluck, Pavan K; Tardiff, Daniel F; Mazzulli, Joseph R; Soldner, Frank; Baru, Valeriya; Lou, Yali; Freyzon, Yelena; Cho, Sukhee; Mungenast, Alison E; Muffat, Julien; Mitalipova, Maisam; Pluth, Michael D; Jui, Nathan T; Schüle, Birgitt; Lippard, Stephen J; Tsai, Li-Huei; Krainc, Dimitri; Buchwald, Stephen L; Jaenisch, Rudolf; Lindquist, Susan

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

Chung, Chee Yeun; Khurana, Vikram; Auluck, Pavan K; Tardiff, Daniel F; Mazzulli, Joseph R; Soldner, Frank; Baru, Valeriya; Lou, Yali; Freyzon, Yelena; Cho, Sukhee; Mungenast, Alison E; Muffat, Julien; Mitalipova, Maisam; Pluth, Michael D; Jui, Nathan T; Schüle, Birgitt; Lippard, Stephen J; Tsai, Li-Huei; Krainc, Dimitri; Buchwald, Stephen L; Jaenisch, Rudolf; Lindquist, Susan.

Affiliation

Chung CY; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Science ; 342(6161): 983-7, 2013 Nov 22.

Article in En | MEDLINE | ID: mdl-24158904

Subject(s)

Benzimidazoles/pharmacology; Neurons/drug effects; Parkinson Disease/metabolism; alpha-Synuclein/metabolism; Animals; Benzimidazoles/chemistry; Endoplasmic Reticulum Stress/drug effects; Female; Humans; Induced Pluripotent Stem Cells/cytology; Induced Pluripotent Stem Cells/metabolism; Mutation; Neurogenesis; Neurons/metabolism; Neurons/pathology; Parkinson Disease/genetics; Rats; alpha-Synuclein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Benzimidazoles / Alpha-Synuclein / Neurons Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Science Year: 2013 Type: Article Affiliation country: United States

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