Interleukin-6 induces malignant transformation of rat mesenchymal stem cells in association with enhanced signaling of signal transducer and activator of transcription 3.

Cui, Xiangrong; Liu, Jianping; Bai, Lu; Tian, Jie; Zhu, Jing

Cui, Xiangrong; Liu, Jianping; Bai, Lu; Tian, Jie; Zhu, Jing.

Affiliation

Cui X; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Cancer Sci ; 105(1): 64-71, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24168060

Subject(s)

Cell Transformation, Neoplastic/metabolism; Interleukin-6/metabolism; Mesenchymal Stem Cells/metabolism; Mesenchymal Stem Cells/pathology; STAT3 Transcription Factor/metabolism; Animals; Astrocytes/cytology; Cell Line, Tumor; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/pathology; Coculture Techniques; Culture Media, Conditioned; Fibroblast Growth Factors; Glioma/genetics; Glioma/metabolism; Glioma/pathology; Interleukin-6/genetics; Janus Kinases/metabolism; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Rats; Rats, Wistar; STAT3 Transcription Factor/genetics; Signal Transduction; Tumor Microenvironment

Key words

Malignant transformation; STAT3; mesenchymal stem cells; tumor microenvironment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Transformation, Neoplastic / Interleukin-6 / STAT3 Transcription Factor / Mesenchymal Stem Cells Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Cancer Sci Year: 2014 Type: Article Affiliation country: China

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