Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome.

Johnson, Thomas V; DeKorver, Nicholas W; Levasseur, Victoria A; Osborne, Andrew; Tassoni, Alessia; Lorber, Barbara; Heller, Janosch P; Villasmil, Rafael; Bull, Natalie D; Martin, Keith R; Tomarev, Stanislav I

Johnson, Thomas V; DeKorver, Nicholas W; Levasseur, Victoria A; Osborne, Andrew; Tassoni, Alessia; Lorber, Barbara; Heller, Janosch P; Villasmil, Rafael; Bull, Natalie D; Martin, Keith R; Tomarev, Stanislav I.

Affiliation

Johnson TV; 1 Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.

Brain ; 137(Pt 2): 503-19, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24176979

Subject(s)

Mesenchymal Stem Cells/metabolism; Neuroprotective Agents/metabolism; Platelet-Derived Growth Factor/metabolism; Retinal Ganglion Cells/metabolism; Animals; Axotomy/adverse effects; Coculture Techniques/methods; Humans; Mesenchymal Stem Cells/pathology; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Retinal Ganglion Cells/pathology

Key words

glaucoma; mesenchymal stem cell; neuroprotection; platelet derived growth factor; retinal ganglion cell

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Ganglion Cells / Platelet-Derived Growth Factor / Neuroprotective Agents / Mesenchymal Stem Cells Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Brain Year: 2014 Type: Article Affiliation country: United States

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