Immunogenicity/hypersensitivity of biologics.

Leach, Michael W; Rottman, James B; Hock, M Benjamin; Finco, Deborah; Rojko, Jennifer L; Beyer, Joseph C

Leach, Michael W; Rottman, James B; Hock, M Benjamin; Finco, Deborah; Rojko, Jennifer L; Beyer, Joseph C.

Affiliation

Leach MW; 1Pfizer Drug Safety Research and Development, Andover, Massachusetts, USA.

Toxicol Pathol ; 42(1): 293-300, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24240973

Subject(s)

Biological Products/administration & dosage; Biological Products/adverse effects; Drug Hypersensitivity; Animals; Antibodies/blood; Drug-Related Side Effects and Adverse Reactions/complications; Drug-Related Side Effects and Adverse Reactions/immunology; Humans; Immunoglobulin E/blood

Key words

antidrug antibodies; biologics; complement; drug development; electron microscopy; hypersensitivity; immunogenicity; immunohistochemistry.

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Drug Hypersensitivity Limits: Animals / Humans Language: En Journal: Toxicol Pathol Year: 2014 Type: Article Affiliation country: United States

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