A naturally derived small molecule disrupts ligand-dependent and ligand-independent androgen receptor signaling in human prostate cancer cells.

Amin, Karishma S; Jagadeesh, Shankar; Baishya, Gakul; Rao, Paruchuri G; Barua, Nabin C; Bhattacharya, Samir; Banerjee, Partha P

Amin, Karishma S; Jagadeesh, Shankar; Baishya, Gakul; Rao, Paruchuri G; Barua, Nabin C; Bhattacharya, Samir; Banerjee, Partha P.

Affiliation

Amin KS; Corresponding Author: Partha P. Banerjee, Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC 20057. ppb@georgetown.edu.

Mol Cancer Ther ; 13(2): 341-52, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24258347

Subject(s)

Carbazoles/pharmacology; Murraya/chemistry; Receptors, Androgen/metabolism; Signal Transduction/drug effects; Androgens/pharmacology; Blotting, Western; CDC2 Protein Kinase/metabolism; Carbazoles/chemistry; Cytoplasm/metabolism; Dihydrotestosterone/pharmacology; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic/drug effects; Humans; Ligands; Male; Microscopy, Fluorescence; Molecular Structure; Phosphorylation/drug effects; Plant Leaves/chemistry; Prostatic Neoplasms/genetics; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; Proteasome Endopeptidase Complex/metabolism; Protein Transport/drug effects; Receptors, Androgen/genetics; Reverse Transcriptase Polymerase Chain Reaction; Serine/metabolism; Signal Transduction/genetics; Transcriptional Activation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbazoles / Signal Transduction / Receptors, Androgen / Murraya Limits: Humans / Male Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2014 Type: Article

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