FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease.

Di Pardo, Alba; Amico, Enrico; Favellato, Mariagrazia; Castrataro, Roberta; Fucile, Sergio; Squitieri, Ferdinando; Maglione, Vittorio

Di Pardo, Alba; Amico, Enrico; Favellato, Mariagrazia; Castrataro, Roberta; Fucile, Sergio; Squitieri, Ferdinando; Maglione, Vittorio.

Affiliation

Di Pardo A; IRCCS Neuromed, 86077 Pozzilli (IS), Italy.

Hum Mol Genet ; 23(9): 2251-65, 2014 May 01.

Article in En | MEDLINE | ID: mdl-24301680

Subject(s)

Huntington Disease/drug therapy; Neurodegenerative Diseases/drug therapy; Propylene Glycols/therapeutic use; Sphingosine/analogs & derivatives; Animals; Brain/drug effects; Brain/metabolism; Brain/pathology; Cell Line; Disease Models, Animal; Fingolimod Hydrochloride; Huntington Disease/metabolism; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Transgenic; Neurodegenerative Diseases/metabolism; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Real-Time Polymerase Chain Reaction; Sphingosine/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propylene Glycols / Sphingosine / Huntington Disease / Neurodegenerative Diseases Type of study: Prognostic_studies Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2014 Type: Article Affiliation country: Italy

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