Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1.

Hashi, Kana; Murata-Kamiya, Naoko; Varon, Christine; Mégraud, Francis; Dominguez-Bello, Maria Gloria; Hatakeyama, Masanori

Hashi, Kana; Murata-Kamiya, Naoko; Varon, Christine; Mégraud, Francis; Dominguez-Bello, Maria Gloria; Hatakeyama, Masanori.

Affiliation

Hashi K; Division of Microbiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Cancer Sci ; 105(3): 245-51, 2014 Mar.

Article in En | MEDLINE | ID: mdl-24354359

Subject(s)

Antigens, Bacterial/genetics; Bacterial Proteins/genetics; Protein Serine-Threonine Kinases/metabolism; Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, Bacterial/chemistry; Antigens, Bacterial/metabolism; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Base Sequence; COS Cells; Chlorocebus aethiops; Dogs; Epithelial Cells/microbiology; Gastric Mucosa/microbiology; Gastric Mucosa/pathology; Humans; Madin Darby Canine Kidney Cells; Molecular Sequence Data; Oncogene Proteins/chemistry; Oncogene Proteins/genetics; Oncogene Proteins/metabolism; Protein Binding; Protein Interaction Domains and Motifs; Protein Serine-Threonine Kinases/chemistry; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism

Key words

CagA; Helicobacter pylori; PAR1b; SHP2; gastric cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Protein Serine-Threonine Kinases / Antigens, Bacterial Limits: Animals / Humans Language: En Journal: Cancer Sci Year: 2014 Type: Article Affiliation country: Japan

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