Biological evaluation of a cytotoxic 2-substituted benzimidazole copper(II) complex: DNA damage, antiproliferation and apoptotic induction activity in human cervical cancer cells.

Qiao, Xin; Ma, Zhong-Ying; Shao, Jia; Bao, Wei-Guo; Xu, Jing-Yuan; Qiang, Zhao-Yan; Lou, Jian-Shi

Qiao, Xin; Ma, Zhong-Ying; Shao, Jia; Bao, Wei-Guo; Xu, Jing-Yuan; Qiang, Zhao-Yan; Lou, Jian-Shi.

Affiliation

Qiao X; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, People's Republic of China.

Biometals ; 27(1): 155-72, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24368745

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Benzimidazoles/chemistry; Copper/chemistry; DNA Damage; DNA/drug effects; Organometallic Compounds/pharmacology; Animals; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Cattle; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Organometallic Compounds/chemical synthesis; Organometallic Compounds/chemistry; Structure-Activity Relationship; Time Factors; Uterine Cervical Neoplasms/genetics; Uterine Cervical Neoplasms/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Benzimidazoles / DNA Damage / DNA / Apoptosis / Copper / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Biometals Journal subject: BIOQUIMICA Year: 2014 Type: Article

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